PT-141 research peptide, also known as Bremelanotide, is a synthetic version of the hormone alpha-MSH. PT-141 is known to activate the melanocortin receptors, which are found in the brain, to stimulate sexual arousal.
In addition to its potential as a sexual stimulant, PT-141 has also been shown to have neuroprotective properties, making it a promising area of research for the treatment of neurodegenerative diseases.
PT-141, also known as Bremelanotide, is a synthetic peptide developed for research purposes, primarily targeting sexual dysfunction and related conditions. Unlike other treatments that focus solely on blood flow, PT-141 works directly on the central nervous system, particularly the melanocortin receptors, to enhance sexual desire and arousal.
This unique action mechanism makes it a promising option for those suffering from hypoactive sexual desire disorder (HSDD) and erectile dysfunction (ED).
Given its potential, many researchers are eager to buy PT-141 to explore its efficacy in various studies. By targeting the central nervous system, PT-141 offers a promising alternative to conventional therapies, opening new avenues for understanding and treating intimate health issues more effectively.
Bremelanotide, operates through a unique mechanism that distinguishes it from other treatments targeting sexual dysfunction. Unlike conventional therapies, which primarily enhance blood flow to the genital area, PT-141 exerts its effects directly on the central nervous system. It specifically targets melanocortin receptors, which are integral to regulating sexual arousal and desire. These receptors are predominantly located in the hypothalamus, a brain region crucial for hormonal balance and motivational behaviours.
Upon administration, PT-141 binds to these melanocortin receptors, initiating a cascade of neurological events. This activation leads to an increase in dopamine levels, a neurotransmitter associated with pleasure and reward, ultimately resulting in heightened intimate desire and arousal. By influencing the brain’s pathways, bremelanotide can stimulate sexual interest and readiness without the need for physical sexual stimuli or arousal.
This central mechanism of action makes PT-141 a versatile therapy beneficial for both men and women experiencing various forms of sexual dysfunction. For individuals with hypoactive sexual desire disorder (HSDD) or erectile dysfunction (ED), bremelanotide offers a targeted, effective solution that addresses the underlying neurological aspects of these conditions, providing a comprehensive approach to improving sexual health.
PubChem CID: 9941379
Molecular Formula: C50H68N14O10
Molecular Weight: 1025.2 g/mol
Sequence:
Ac-Nle-Asp(1)-His-D-Phe-Arg-Trp-Lys(1)-OH
Source: PubChem
View our PT-141 High-Performance Liquid Chromatography (HPLC) Certificate here.
PT-141 Nasal Spray
Buy PT-141 nasal spray (Bremelanotide) from Norway Direct Sarms, available in size 15ml and 30ml bottles for research studies.
PT-141 Peptide Vial
Buy PT-141 Peptide 10mg Vial for research from Direct Sarms Norway. Also available as a kit, which includes bacteriostatic water and syringes. This offers convenience to researchers by simplifying the process of reconstituting the peptide.
What is the legal status of PT-141?
While the U.S. Food and Drug Administration (FDA) has approved PT-141, branded as Vyleesi, for treating hypoactive sexual desire disorder (HSDD) in premenopausal women, its approval is currently restricted to this specific use. Its regulatory status differs across various regions and therefore researchers need to know the laws in their own region.
In the United Kingdom, PT-141 has not yet received approval from the Medicines and Healthcare products Regulatory Agency (MHRA). Consequently, its usage remains limited to clinical trials and off-label prescriptions. Healthcare professionals and researchers continue to monitor ongoing studies and regulatory developments to determine its future availability in the UK market.
Similarly, in Australia, PT-141 has not been approved by the Therapeutic Goods Administration (TGA). The absence of regulatory approval signifies that bremelanotide is not yet commercially available for the treatment of HSDD. However, like in the UK, ongoing research and clinical trials are closely scrutinised, and future approval may depend on further evidence of efficacy and safety.
Both the UK and Australia are expected to follow the global scientific community’s evaluations of bremelanotide’s therapeutic potential, which may eventually influence regulatory decisions.
What are the side effects of PT-141?
Like many research peptides, bremelanotide comes with potential side effects, including redness, nausea, headaches, and occasional discomfort at the injection site. It’s crucial for researchers to monitor participants closely and instruct them to report any adverse effects immediately.
Prompt reporting allows for swift medical attention and necessary adjustments to patient care strategies, ensuring the safety and well-being of all participants.
Can PT-141 help with weight loss?
Preliminary research suggests that PT-141 may aid in weight management by reducing body fat and improving metabolism, although more studies are needed to confirm these findings.
How should bremelanotide be stored?
Bremelanotide should be stored according to the supplier’s guidelines, usually in a cool, dry place away from direct sunlight, to maintain its stability and efficacy.
For more information, explore our latest blog posts dedicated to PT-141 peptides.
Researchers looking to buy PT-141 for their studies can find it available in various forms such as nasal sprays and subcutaneous injections (e.g., the peptide vial and the PT-141 Pre-mixed Pen 10mg). When considering to Buy PT-141, it is essential to source from reputable suppliers, such as Norway Direct Sarms, to ensure the quality and integrity of the peptide, which is fundamental for achieving reliable and consistent research outcomes.
[1] J.G.Pfaus, A.Shadiack, T.Van.Soest, et al (2004) Selective facilitation of sexual solicitation in the female rat by a melanocortin receptor agonist – Proceedings of the National Academy of Sciences USA, 2004 Jul 6;101(27):10201-4.
[2] A.H.Clayton, S.E.Althof, S.Kingsberg, et al (2016) Bremelanotide for Female Sexual Dysfunctions in Premenopausal Women: A Randomized, Placebo-Controlled Dose-Finding Trial – Sage Journals, Womens Health (Lond), 2016 Jun;12(3):325-37.
[3] R.E.Nappi, K.Wawra, and S.Schmitt (2006) Hypoactive sexual desire disorder in postmenopausal women – Gynecological Endocrinology, 2006 Jun;22(6):318-23.
[4] M.K.Miller, J.R.Smith, J.J.Norman, et al (2018) Expert opinion on existing and developing drugs to treat female sexual dysfunction – Expert Opinion Emerging Drugs, 2018 Sep;23(3):223-230.
[5] J.A.Simon, S.A.Kingsberg, D.Portman, et al (2019) Long-Term Safety and Efficacy of Bremelanotide for Hypoactive Sexual Desire Disorder – Obstetrics and Gynecology, 2019 Nov; 134(5): 909–917.
[6] A.N.Edinoff, N.M.Sanders, K.B.Lewis, et al (2022) Bremelanotide for Treatment of Female Hypoactive Sexual Desire – Neurology International, 2022 Mar; 14(1): 75–88.
[7] C.Spana, R.Jordan, S.Fischkoff (2022) Effect of bremelanotide on body weight of obese women: Data from two phase 1 randomized controlled trials – Diabetes Obesity and Metabolism, 2022 Jun;24(6):1084-1093.
[8] Hai-xia Ji ,Yu-lian Zou ,Jing-jing Duan, et al (2013) The Synthetic Melanocortin (CKPV)2 Exerts Anti-Fungal and Anti-Inflammatory Effects against Candida albicans Vaginitis via Inducing Macrophage M2 Polarization – PLOS One Journal, Published: February 14, 2013.
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